Product Introduction
| Product Name |
4-(Perfluoropropan-2-yl)aniline |
| Product Description |
White to off-white Powder |
|
CAS Number |
2396-17-0 |
|
Purity |
≥99% |
|
Total impurity |
≤1% |
|
Single impurity |
≤0.5% |
|
Molecular Formula |
C9H6F7N |
|
Molecular Weight |
261.14 |
|
Retest period |
12 months |
|
Storage Condition |
Store at room temperature |
|
COA/ROS/MSDS/MOA |
Provided |
Chemical Name
4-(Perfluoropropan-2-yl)aniline
The CAS number for 4-(Perfluoropropan-2-yl)aniline is 2396-17-0
The Molecular Formula of 4-(Perfluoropropan-2-yl)aniline is C9H6F7N
Keywords
4-(Perfluoropropan-2-yl)aniline
CAS 2396-17-0
APPLICATION
1. Pharmaceutical field
Synthesis of fluorinated drugs
Fluorinated groups can improve the metabolic stability, lipid solubility and bioavailability of drugs. This intermediate may be used for:
Antitumor drugs: such as building blocks for kinase inhibitors.
Antidepressant/antipsychotic drugs: Fluorinated aromatic amines are common in central nervous system drugs.
Antibacterial agents: Perfluoroalkyl groups enhance membrane penetration.
Example reference
Similar structures can be found in Pfizer's anti-new crown drug Paxlovid (a fragment containing trifluoromethyl), or Merck's Janus kinase inhibitors.
2. Pesticides and herbicides
High-efficiency fluorinated pesticides
The strong electron-withdrawing property of perfluoroisopropyl can enhance the interaction between pesticides and target enzymes:
Insecticides: such as the modification of neonicotinoid compounds.
Herbicides: used to synthesize acetolactate synthase (ALS) inhibitors.
3. Materials Science
Liquid Crystal Materials (LC)
Fluorinated aniline is a common intermediate of liquid crystal molecules, used in:
Display devices: Perfluoroisopropyl improves the dielectric anisotropy and low temperature performance of liquid crystals.
Polymer Materials
Fluorinated polymers: As monomers or modifiers, improve the weatherability of materials.
Surface treatment agents: Used in hydrophobic/oleophobic coatings.
4. Dyes and Pigments
High-performance fluorinated dyes
Textile dyes: Enhance color fastness and UV resistance.
Optoelectronic materials: Used in hole transport layers of organic semiconductors or OLEDs.
5. Organic Synthesis and Catalysis
Ligand Design
As a component of chiral ligands (such as fluorinated BINAP derivatives) for asymmetric hydrogenation reactions.
Fluorination Reagents
Introducing other fluorinated groups through derivatization (such as diazotization).
6. Other Fields
Fluorescent Probes
Fluorinated aromatic amines can be designed as bioimaging probes (such as pH or metal ion sensors).
Electronic Chemicals
Fluorinated components used in photoresists or semiconductor cleaning agents.
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